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On March 13, 1961, President John F. Kennedy announced the Alliance for Progress, an economic assistance program to promote political democracy, economic growth, and social justice in Latin America. The United States and Latin American nations formally agreed to the alliance at a conference held in August 1961, at Punta del Este, Uruguay. U.S. delegates promised that Latin America would receive over twenty billion dollars in public and private capital from the United States and international lending authorities during the 1960s. The money would arrive in the form of grants, loans, and direct private investments. When combined with an expected eighty billion dollars in internal investment, this new money was projected to stimulate an economic growth rate of not less than 2.5 percent a year. This economic growth would facilitate significant improvements in employment, and in rates of infant mortality, life expectancy, and literacy rates. In agreeing to the alliance, Latin American leaders pledged to work for equality and social justice by promoting agrarian reform and progressive income taxes.

The Kennedy administration developed this so-called Marshall Plan for Latin America because it judged the region susceptible to social revolution and communism. Fidel Castro had transformed the Cuban Revolution into a strident anti-American movement and had allied his nation with the Soviet Union. U.S. officials feared that the lower classes of Latin America, mired in poverty and injustice, might follow similarly radical leaders.

Alliance programs delivered outside capital to the region, but the Alliance for Progress failed to transform Latin America. During the 1960s, Latin American economies performed poorly, usually falling below the 2.5 percent target. The region witnessed few improvements in health, education, or welfare. Latin American societies remained unfair and authoritarian. Sixteen extra-constitutional changes of government repeatedly unsettled the region.

The Alliance for Progress fell short of its goals for several reasons. Latin America had formidable obstacles to change: elites resisted land reform, equitable tax systems, and social programs; new credits often brought greater indebtedness rather than growth; and the Marshall Plan experience served as a poor guide to solving the problems of a region that was far different from Western Europe. The United States also acted ambiguously, calling for democratic progress and social justice, but worried that Communists would take advantage of the instability caused by progressive change. Further, Washington provided wholehearted support only to those Latin American governments and organizations that pursued fervent anticommunist policies.

On December 8, 1953, in the midst of increasing nuclear weapons testing and geopolitical polarization, United States President Dwight D. Eisenhower launched the Atoms for Peace initiative. More than a pacifist program, the initiative is nowadays seen as an essential piece in the U.S. defense strategy and foreign policy at the beginning of the Cold War. As such, it pursued several ambitious goals, and Latin America was an ideal target for most of them: to create political allies, to ease fears of the deadly atomic energy while fostering receptive attitudes towards nuclear technologies, to control and avoid development of nuclear weapons outside the United States and its allies, and to open or redirect markets for the new nuclear industry. The U.S. Department of State, through the Foreign Operations Administration, acted in concert with several domestic and foreign middle-range actors, including people at national nuclear commissions, universities, and industrial funds, to implement programs of regional technical assistance, education and training, and technological transfer.

Latin American countries were classified according to their stage of nuclear development, with Brazil at the top and Argentina and Mexico belonging to the group of “countries worthy of attention.” Nuclear programs often intersected with development projects in other areas, such as agriculture and public health. Moreover, Eisenhower’s initiative required the recruitment of local actors, natural resources and infrastructures, governmental funding, and standardized (but localized techno-scientific) practices from Latin American countries. As Atoms for Peace took shape, it began to rely on newly created multilateral and regional agencies, such as the International Atomic Energy Agency (IAEA) of the United Nations and the Inter-American Nuclear Energy Commission (IANEC) of the Organization of American States (OAS).

Nevertheless, as seen from Latin America, the implementation of atomic energy for peaceful purposes was reinterpreted in different ways in each country. This fact produced different outcomes, depending on the political, economic, and techno-scientific expectations and interventions of the actors involved. It provided, therefore, an opportunity to create local scientific elites and infrastructure. Finally, the peaceful uses of atomic energy allowed the countries in the region to develop national and international political discourses framing the Treaty for the Prohibition of Nuclear Weapons in Latin America and the Caribbean signed in Tlatelolco, Mexico City, in 1967, which made Latin America the first atomic weapons–free populated zone in the world.

The drug trade in Mexico and efforts by the Mexican government—often with United States assistance—to control the cultivation, sale, and use of narcotics are largely 20th-century phenomena. Over time, U.S. drug control policies have played a large role in the scope and longevity of Mexico’s drug trade. Many argue that these policies—guided by the U.S.-led global war on drugs—have been fruitless in Mexico, and are at least partially responsible for the violence and instability seen there in the early twentieth century.

A producer of Cannabis sativa and the opium poppy, Mexico emerged as a critical place of drug supply following World War II, even though domestic drug use in Mexico has remained low. Since the 1960s and 1970s, the drug trade in Mexico has reached epic proportions due to drug demand emanating from the United States. Mexico’s cultivation of psychoactive raw materials and its prime location—connecting North America with Central America and the Caribbean and sharing a 2,000-mile-long border with the United States—have made it an ideal transit point for narcotics originating from other parts of the Western Hemisphere and the world. Although Mexico implemented a smaller, less organized antidrug campaign in the late 1940s, the inauguration of the global war on drugs in 1971 represents a distinctive shift in its drug control and enforcement policies. The government began utilizing U.S. supply-control models, advice, and aid to decrease the cultivation of drugs inside the country. America’s fight against drug trafficking in Central America and the Caribbean in the 1980s and 1990s shifted the geographic locus of the drug trade to Mexico by the early 2000s. Mexico’s powerful drug cartels proved more than capable of eluding (sometimes colluding with) the Mexican government’s efforts against them in the first decade of the 21st century during the administration of President Felipe Calderón (2006–2012). Calderón’s fight against the cartels brought about a drug war in Mexico, characterized by widespread violence, instability, and an estimated death toll of more than 70,000 people.

In the first three decades of the 20th century, the United States regularly intervened militarily in the circum-Caribbean, sending the Marines to govern directly or rule by proxy in Nicaragua (1912–1933), Haiti (1915–1934), and the Dominican Republic (1916–1924). The end of this era of U.S. occupations, and the relatively harmonious period that followed, is typically credited to President Franklin D. Roosevelt’s Good Neighbor Policy, although his predecessor Herbert Hoover began the process and both drew upon Latin American traditions and yielded to Latin American pressures to change traditional U.S. policy. The new approach to relations with Latin America included not only abjuring the use of military force but respecting the full sovereignty of Latin American states by not interfering or even commenting upon their processes of political succession. The Roosevelt administration signed agreements formalizing this new respect and sought to negotiate mutually beneficial trade agreements with Latin American countries. The benefits of the Good Neighbor Policy became evident when nearly every country in the region aligned itself with the United States in World War II. Measures taken against Axis nationals strained the policy during the war. By 1945, and during the Cold War, the policy unraveled, as the United States resumed both interference (in Argentine politics) and intervention (with a CIA-organized coup in Guatemala in 1954).

At the moment of its founding in 1920, the League of Nations enjoyed the solid support of Latin American countries, whose early and extensive participation helped legitimize the new international system and facilitate the functioning of its institutional representation. While this support was tremendously valuable for the Geneva-based League, it continuously suffered temporary, though significant, lapses on the part of nations that were particularly representative of the region, such as Argentina, Brazil and Mexico. Despite the characteristically pacifist rhetoric enunciated by this group of states, Latin American support cannot be called disinterested or sincere. Indeed, their collaboration with the multilateral and universalistic pretensions of the League was notoriously reserved, to such an extent that in the 1920s the organization’s General Secretariat granted them special treatment and prerogatives, while simultaneously ensuring that the League would continue to exert its influence in the Western Hemisphere. This reality was confirmed, sadly, in the context of two conflicts, the Chaco and Leticia wars, during which Latin American loyalty to the League became seriously questioned. With few exceptions in the decade that followed—one characterized by complicated crises that would lead to a new worldwide conflagration—the general tendency with respect to the system of collective security described in the Society’s Charter was scarred by dissatisfaction, incompliance, and increasing disillusionment that undoubtedly contributed to the weakening and eventual collapse of this organization so emblematic of the interwar period.